Euphorikanin A, a Diterpenoid Lactone with a Fused 5/6/7/3 Ring System from Euphorbia kansui
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- 作者：Dong-Qing Fei ; Le-Le Dong ; Feng-Ming Qi ; Gai-Xia Fan ; Hui-Hong Li ; Zheng-Yu Li ; Zhan-Xin Zhang
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：June 17, 2016
- 年：2016
- 卷：18
- 期：12
- 页码：2844-2847
- 全文大小：306K
- 年卷期：0
- ISSN：1523-7052
文摘
Euphorikanin A (1), an unprecedented diterpenoid lactone which possesses a novel 5/6/7/3-fused tetracyclic ring skeleton, was isolated from the roots of Euphorbia kansui. The chemical structure and absolute stereochemistry were elucidated on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis. Compound 1 exhibited moderate cytotoxicity against two human tumor cell lines HeLa and NCI-446. A proposed biosynthetic pathway of compound 1 is also described.