Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room Temperature
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- 作者：Feng-Cheng Jia ; Zhi-Wen Zhou ; Cheng Xu ; Yan-Dong Wu ; An-Xin Wu
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：June 17, 2016
- 年：2016
- 卷：18
- 期：12
- 页码：2942-2945
- 全文大小：382K
- 年卷期：0
- ISSN：1523-7052
文摘
A synergetic tert-butyl hydroperoxide/K3PO4-promoted oxidative cyclization has been developed for the facile synthesis of various functionalized quinazolin-4(3H)-ones from commercially available isatins and amidine hydrochlorides at room temperature. The synthetic utility of this strategy was illustrated by the convenient synthesis of tryptanthrin derivatives via a self-dimerization of isatins under the same conditions.