Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico

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• 作者：Kelly K. Ferguson ; David E. Cantonwine ; Luis O. Rivera-Gonz谩lez ; Rita Loch-Caruso ; Bhramar Mukherjee ; Liza V. Anzalota Del Toro ; Braulio Jim茅nez-V茅lez ; Antonia M. Calafat ; Xiaoyun Ye ; Akram N. Alshawabkeh ; Jos茅 F. Cordero ; John D. Meeker
• 刊名：Environmental Science & Technology
• 出版年：2014
• 出版时间：June 17, 2014
• 年：2014
• 卷：48
• 期：12
• 页码：7018-7025
• 全文大小：242K
• 年卷期：v.48,no.12(June 17, 2014)
• ISSN：1520-5851

文摘

Phthalate exposure during pregnancy has been linked to adverse birth outcomes such as preterm birth, and inflammation and oxidative stress may mediate these relationships. In a prospective cohort study of pregnant women recruited early in gestation in Northern Puerto Rico, we investigated the associations between urinary phthalate metabolites and biomarkers of inflammation, including C-reactive protein, IL-1尾, IL-6, IL-10, and TNF-伪, and oxidative stress, including 8-hydroxydeoxyguanosine (OHdG) and 8-isoprostane. Inflammation biomarkers were measured in plasma twice during pregnancy (N = 215 measurements, N = 120 subjects), and oxidative stress biomarkers in urine were measured three times (N = 148 measurements, N = 54 subjects) per woman. In adjusted linear mixed models, metabolites of di-2-ethylhexyl phthalate (DEHP) were associated with increased IL-6 and IL-10 but relationships were generally not statistically significant. All phthalates were associated with increases in oxidative stress markers. Relationships with OHdG were significant for DEHP metabolites as well as mono-n-butyl phthalate (MBP) and monoiso-butyl phthalate (MiBP). For 8-isoprostane, associations with nearly all phthalates were statistically significant and the largest effect estimates were observed for MBP and MiBP (49鈥?0% increase in 8-isoprostane with an interquartile range increase in metabolite concentration). These relationships suggest a possible mechanism for phthalate action that may be relevant to a number of adverse health outcomes.