Oroidin Inhibits the Activity of the Multidrug Resistance Target Pdr5p from Yeast Plasma Membranes

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• 作者：Fernanda R. da Silva ; Ana Claudia Tessis ; Patricia F. Ferreira ; Luciana P. Rangel ; Aline S. Garcia-Gomes ; Fabio R. Pereira ; Roberto G. S. Berlinck ; Guilherme Muricy ; Antonio Ferreira-Pereira
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：February 25, 2011
• 年：2011
• 卷：74
• 期：2
• 页码：279-282
• 全文大小：734K
• 年卷期：v.74,no.2(February 25, 2011)
• ISSN：1520-6025

文摘

Oroidin was isolated from the marine sponge Agelassventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.