Examining the Complex Regulation and Drug-Induced Plasticity of Dopamine Release and Uptake Using Voltammetry in Brain Slices
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- 作者：Mark J. Ferris ; Erin S. Calipari ; Jordan T. Yorgason ; Sara R. Jones
- 刊名：ACS Chemical Neuroscience
- 出版年：2013
- 出版时间：May 15, 2013
- 年：2013
- 卷：4
- 期：5
- 页码：693-703
- 全文大小：341K
- 年卷期：v.4,no.5(May 15, 2013)
- ISSN：1948-7193
文摘
Fast scan cyclic voltammetry in brain slices (slice voltammetry) has been used over the last several decades to increase substantially our understanding of the complex local regulation of dopamine release and uptake in the striatum. This technique is routinely used for the study of changes that occur in the dopamine system associated with various disease states and pharmacological treatments, and to study mechanisms of local circuitry regulation of dopamine terminal function. In the context of this Review, we compare the relative advantages of voltammetry using striatal slice preparations versus in vivo preparations, and highlight recent advances in our understanding of dopamine release and uptake in the striatum specifically from studies that use slice voltammetry in drug-na茂ve animals and animals with a history of psychostimulant self-administration.