The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice
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- 作者：Jelena Kolosnjaj-Tabi ; Yasir Javed ; L茅naic Lartigue ; Jeanne Volatron ; Dan Elgrabli ; Iris Marangon ; Giammarino Pugliese ; Benoit Caron ; Albert Figuerola ; Nathalie Luciani ; Teresa Pellegrino ; Damien Alloyeau ; Florence Gazeau
- 刊名：ACS Nano
- 出版年：2015
- 出版时间：August 25, 2015
- 年：2015
- 卷：9
- 期：8
- 页码：7925-7939
- 全文大小：1115K
- ISSN：1936-086X
文摘
Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.