An Efficient Liquid Chromatography-Mass Spectrometry Interface for the Generation of Electron Ionization Spectra

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• 作者：Achille Cappiello ; Michael Balogh ; Giorgio Famiglini ; Filippo Mangani ; and Pierangela Palma
• 刊名：Analytical Chemistry
• 出版年：2000
• 出版时间：August 15, 2000
• 年：2000
• 卷：72
• 期：16
• 页码：3841 - 3846
• 全文大小：136K
• 年卷期：v.72,no.16(August 15, 2000)
• ISSN：1520-6882

文摘

The use of a new LC-MS interface (cap-EI), part of aWaters Integrity system, capable of generating EI spectraat micro flow rates is presented. The cap-EI interfacerelies on the production of a fine aerosol by means of anebulizer and supported by a nitrogen jet. Sensitivity,response linearity, reproducibility, and LC compatibilityof the interface were thoroughly examined using testosterone, caffeine, a mixture of antiinflammatory drugs, and3,4-dihydroxybenzoic acid as test compounds. The interface is fully compatible with LC requirements such ashigh-water- and/or -buffer-content mobile phases. Reproducibility, high sensitivity in scan mode, as well, toproduce library-searchable EI spectra, 2 orders of magnitude linearity, together with an intrinsic simplicity of theentire system are the key features of cap-EI interface.