N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

详细信息    查看全文

• 作者：Stephen S. Nyandoro ; Joseph Ndanu ; Joan J. E. Munissi ; Amra Gruhonjic ; Paul A. Fitzpatrick ; G枚ran Landberg ; Yu Lu ; Bin Wang ; Fangfang Pan ; Kari Rissanen ; M谩t茅 Erd茅lyi
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：August 28, 2015
• 年：2015
• 卷：78
• 期：8
• 页码：2045-2050
• 全文大小：314K
• ISSN：1520-6025

文摘

Seven N-cinnamoyltetraketides (1鈥?b>7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3鈥?07.7 渭M) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED₅₀ 15.3鈥?05.7 渭M) against the MDA-MB-231 triple negative aggressive breast cancer cell line.