Amphipathic 伪-Helix Mimetics Based on a 1,2-Diphenylacetylene Scaffold
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- 作者：Kwan-Young Jung ; Kenno Vanommeslaeghe ; Maryanna E. Lanning ; Jeremy L. Yap ; Caryn Gordon ; Paul T. Wilder ; Alexander D. MacKerell ; Jr. ; Steven Fletcher
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：July 5, 2013
- 年：2013
- 卷：15
- 期：13
- 页码：3234-3237
- 全文大小：288K
- 年卷期：v.15,no.13(July 5, 2013)
- ISSN：1523-7052
文摘
In order to mimic amphipathic 伪-helices, a novel scaffold based on a 1,2-diphenylacetylene was designed. NMR and computational modeling confirmed that an intramolecular hydrogen bond favors conformations of the 1,2-diphenylacetylene that allow for accurate mimicry of the i, i + 7 and i + 2, i + 5 side chains found on opposing faces of an 伪-helix.