Hybrid Fluorinated and Hydrogenated Double-Chain Surfactants for Handling Membrane Proteins

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• 作者：Fréderic Legrand ; Cécile Breyton ; Pierre Guillet ; Christine Ebel ; Grégory Durand
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：January 15, 2016
• 年：2016
• 卷：81
• 期：2
• 页码：681-688
• 全文大小：389K
• ISSN：1520-6904

文摘

Two hybrid fluorinated double-chain surfactants with a diglucosylated polar head were synthesized. The apolar domain consists of a perfluorohexyl main chain and a butyl hydrogenated branch as a side chain. They were found to self-assemble into small micelles at low critical micellar concentrations, demonstrating that the short branch increases the overall hydrophobicity while keeping the length of the apolar domain short. They were both able to keep the membrane protein bacteriorhodopsin stable, one of them for at least 3 months.