Teotihuacanin, a Diterpene with an Unusual Spiro-10/6 System from Salvia amarissima with Potent Modulatory Activity of Multidrug Resistance in Cancer Cells
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- 作者：Elih煤 Bautista ; Mabel Fragoso-Serrano ; Rub茅n A. Toscano ; Mar铆a del Rosario Garc铆a-Pe帽a ; Alfredo Ortega
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：July 2, 2015
- 年：2015
- 卷：17
- 期：13
- 页码：3280-3282
- 全文大小：238K
- ISSN：1523-7052
文摘
Teotihuacanin (1), an unusual rearranged clerodane diterpene with a new carbon skeleton containing a spiro-10/6 bicyclic system, was isolated from the leaves and flowers of Salvia amarissima. Its structure was determined through spectroscopic analyses. Its absolute configuration was established by single-crystal X-ray diffraction. Compound 1 showed potent modulatory activity of multidrug resistance in vinblastine-resistant MCF-7 cancer cell line (reversal fold, RFMCF-7/Vin+ > 10703) at 25 渭g/mL.