Diastereoselective Synthesis of Indanes and Tetralins via Intramolecular Friedel鈥揅rafts Reaction

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• 作者：Jeanne-Marie Begouin ; Francesca Capitta ; Xian Wu ; Meike Niggemann
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：March 15, 2013
• 年：2013
• 卷：15
• 期：6
• 页码：1370-1373
• 全文大小：239K
• 年卷期：v.15,no.6(March 15, 2013)
• ISSN：1523-7052

文摘

An easy access to tetralin and indane skeletons has been developed using a diastereoselective intramolecular Friedel鈥揅rafts alkylation. Treatment of diastereomeric mixtures of benzyl carbinols with a catalytic amount of Ca(NTf₂)₂/Bu₄NPF₆ yields the respective tetralin or indane in good yields with high levels of regio- and diastereoselectivity.