1,3,5-Trisubstituted and 5-Acyl-1,3-Disubstituted Hydantoin Derivatives via Novel Sequential Three-Component Reaction

详细信息    查看全文

• 作者：Orazio A. Attanasi ; Lucia De Crescentini ; Gianfranco Favi ; Simona Nicolini ; Francesca Romana Perrulli ; Stefania Santeusanio
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：February 4, 2011
• 年：2011
• 卷：13
• 期：3
• 页码：353-355
• 全文大小：142K
• 年卷期：v.13,no.3(February 4, 2011)
• ISSN：1523-7052

文摘

1,2-Diaza-1,3-dienes (DDs) react as Michael acceptors with primary amines to afford 伪-aminohydrazone derivatives that were in situ coupled with isocyanates. Intramolecular ring closure of the asymmetric urea derivatives so formed allows for a selectively substituted hydantoin ring to be obtained. The hydrazone side chain introduced by the conjugated heterodiene system at the 5-position of the heterocycle represents a valuable functionality for accessing novel 5-acyl derivatives difficult to obtain by other methods.