A Synthetic Divalent Cholera Toxin Glycocalix[4]arene Ligand Having Higher Affinity than Natural GM1 Oligosaccharide
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- 作者：Daniela Arosio ; Marco Fontanella ; Laura Baldini ; Laura Mauri ; Anna Bernardi ; Alessandro Casnati ; Francesco Sansone ; and Rocco Ungaro
- 刊名：Journal of the American Chemical Society
- 出版年：2005
- 出版时间：March 23, 2005
- 年：2005
- 卷：127
- 期：11
- 页码：3660 - 3661
- 全文大小：51K
- 年卷期：v.127,no.11(March 23, 2005)
- ISSN：1520-5126
文摘
A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene 1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide.