Effect of a Tomato-Based Drink on Markers of Inflammation, Immunomodulation, and Oxidative Stress
详细信息 查看全文
- 作者：Patrizia Riso ; Francesco Visioli ; Simona Grande ; Serena Guarnieri ; Claudio Gardana ; Paolo Simonetti ; and Marisa Porrini
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2006
- 出版时间：April 5, 2006
- 年：2006
- 卷：54
- 期：7
- 页码：2563 - 2566
- 全文大小：56K
- 年卷期：v.54,no.7(April 5, 2006)
- ISSN：1520-5118
文摘
Regular consumption of tomato and its products is being consistently associated with lower risk ofseveral types of cancer and, to a lesser extent, coronary heart disease. Among the many tomatocomponents credited with healthful properties, carotenoids and particularly lycopene are being activelyinvestigated. Given the recognized role of immune/inflammatory processes in atherogenesis, theeffects of a tomato-based drink (Lyc-o-Mato), which was previously shown to afford DNA protectionfrom oxidative stress, on the modulation of immune and inflammatory markers (by enzymeimmunoessay), on basal lymphocyte DNA damage (by comet assay), and on F2-isoprostane excretion(by LC-MS/MS), were investigated in 26 healthy young volunteers. In a placebo-controlled, double-blind, crossover study, Lyc-o-Mato (5.7 mg of lycopene, 3.7 mg of phytoene, 2.7 mg of phytofluene,1 mg of 
-carotene, and 1.8 mg of 
-tocopherol) or a placebo drink (same taste and flavor, but devoidof active compounds) were given for 26 days, separated by a wash-out period. During the studysubjects maintained their habitual, hence unrestricted, diet. TNF- production by whole blood was34.4% lower after 26 days of drink consumption, whereas the other parameters were not significantlymodified by the treatment. In turn, modest effects of the regular intake of a tomato drink, providingsmall amounts of carotenoids, were found on the production of inflammatory mediators, such asTNF-, in young healthy volunteers. Future intervention trials in subjects with low carotenoid statusand/or compromised immune system will resolve the issue of whether carotenoids modulate immuneparameters in humans.Keywords: Tomato; inflammation; immunomodulation; oxidative stress; carotenoids; lycopene; TNF-
-carotene, and 1.8 mg of -tocopherol) or a placebo drink (same taste and flavor, but devoidof active compounds) were given for 26 days, separated by a wash-out period. During the studysubjects maintained their habitual, hence unrestricted, diet. TNF- production by whole blood was34.4% lower after 26 days of drink consumption, whereas the other parameters were not significantlymodified by the treatment. In turn, modest effects of the regular intake of a tomato drink, providingsmall amounts of carotenoids, were found on the production of inflammatory mediators, such asTNF-, in young healthy volunteers. Future intervention trials in subjects with low carotenoid statusand/or compromised immune system will resolve the issue of whether carotenoids modulate immuneparameters in humans.Keywords: Tomato; inflammation; immunomodulation; oxidative stress; carotenoids; lycopene; TNF-