Cytotoxic Diterpenoids from Croton argyrophylloides

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• 作者：Hlcio S. Santos ; Francisco W. A. Barros ; Maria Rose Jane R. Albuquerque ; Paulo N. Bandeira ; Cladia Pessoa ; Raimundo Braz-Filho ; Francisco J. Q. Monte ; Jose Henrique Leal-Cardoso ; Telma L. G. Lemos
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：October 23, 2009
• 年：2009
• 卷：72
• 期：10
• 页码：1884-1887
• 全文大小：127K
• 年卷期：v.72,no.10(October 23, 2009)
• ISSN：1520-6025

文摘

Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1−3.