Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots

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• 作者：Hak Soo Choi ; Binil Itty Ipe ; Preeti Misra ; Jeong Heon Lee ; Moungi G. Bawendi ; John V. Frangioni
• 刊名：Nano Letters
• 出版年：2009
• 出版时间：June 10, 2009
• 年：2009
• 卷：9
• 期：6
• 页码：2354-2359
• 全文大小：385K
• 年卷期：v.9,no.6(June 10, 2009)
• ISSN：1530-6992

文摘

A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.