A Cell Wall-Active Lipopeptide from the Fungus Pochonia bulbillosa

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• 作者：Frank E. Koehn ; Donald R. Kirsch ; Xidong Feng ; Jeffrey Janso ; Mairead Young
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：December 26, 2008
• 年：2008
• 卷：71
• 期：12
• 页码：2045-2048
• 全文大小：113K
• 年卷期：v.71,no.12(December 26, 2008)
• ISSN：1520-6025

文摘

Bioassay-directed fractionation of a fermentation of Pochonia bulbinosa, culture 38G272, led to the isolation of a series of structurally novel, prospective cell wall-active lipopeptides. The main component of this suite is 1, a linear hexapeptide with a δ-hydroxymyristic acid amide substituted N-terminus. The structure was deduced using high-field microsample NMR, Fourier transform mass spectrometry, and microscale chemical degradation. The potent cell wall activity and synthetically accessible structure of 1 make it a potential lead for further investigation.