Preparation of 2-Iodo Allylic Alcohols from 2-Butyn-1,4-diol

详细信息    查看全文

• 作者：Douglass F. Taber ; M. Inthikhab Sikkander ; James F. Berry ; Kevin J. Frankowski
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：February 15, 2008
• 年：2008
• 卷：73
• 期：4
• 页码：1605 - 1607
• 全文大小：58K
• 年卷期：v.73,no.4(February 15, 2008)
• ISSN：1520-6904

文摘

jo7021197n00001>

journals/joceah/73/i04/figures/jo7021197n00001.gif" ALIGN="left" HSPACE=5>

The conversion of 2-butyn-1,4-diol to (Z)-2,4-diiodobut-2-en-1-ol proceeded efficiently using in situ generated trimethylsilyl iodide. Coupling with Grignard reagents andother nucleophiles delivered (2Z)-2-iodo allylic alcohols. Thegeometry of the products was established by nOe.