文摘
Highly stereoselective Mn-mediated couplings of alkyl iodides with chiral N-acylhydrazones bearing ester functionality afford a series of γ-hydrazino esters, including γ-substituted, α,γ-disubstituted, and α,α,γ-trisubstituted examples. In contrast to prior work with chiral N-acylhydrazones, high stereoselectivity was observed even in the absence of Lewis acid. Microwave-assisted acylation with trifluoroacetic anhydride and reductive N−N bond cleavage provided the γ-amino ester functionality in a synthetically useful N-TFA-protected form.