This paper summarizes t
he recent activities of t
he Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed 鈥渕issing proteins鈥? in biological samples that lack sufficient experimental evidence at t
he protein level for confident protein identification. T
he C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms t
he basis of t
he C-HPP鈥檚 activities; t
herefore, we have summarized some of t
he key approac
hes and t
heir roles in t
he project. We present new analytical technologies that improve t
he c
hemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support t
he development of analytical assays. Most of this paper鈥檚 content has been compiled from posters, slides, and discussions presented in t
he series of C-HPP workshops
held during 2014. All data (posters, presentations) used are available at t
he C-HPP Wiki (
http://c-hpp.webhosting.rug.nl/) and in the Supporting Information.