Alkylbenzoquinone Involved in Development of Cellular Slime Molds

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• 作者：Yoshiaki Takaya ; Rie Hotta ; Kenshu Fujiwara ; Risa Otani ; Yurika Uchiyama ; Mizuki Sakakibara ; Eri Fukuda ; Masatake Niwa ; Kei Inouye ; Akiko A. Oohata
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：July 18, 2014
• 年：2014
• 卷：16
• 期：14
• 页码：3660-3663
• 全文大小：280K
• ISSN：1523-7052

文摘

The structure of the prespore-cell-promoting factor from Dictyostelium discoideum was determined to be 2-hydroxy-5-methyl-6-pentylbenzoquinone. The synthetic compound has prespore-cell-promoting activity similar to the natural one, with half-maximal induction at a concentration as low as 40 pM. It was also found that the factor induces aggregation in an aggregation-deficient mutant of a related species, Polysphodilium violaceum. Both these activities are sensitive to positional isomerism with the 6-methyl-5-pentyl isomer showing no detectable activity.