Total Synthesis of Thelephantin O, Vialinin A/Terrestrin A, and Terrestrins B鈥揇

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• 作者：Kenshu Fujiwara ; Takuto Sato ; Yusuke Sano ; Toshio Norikura ; Ryo Katoono ; Takanori Suzuki ; Hajime Matsue
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：June 1, 2012
• 年：2012
• 卷：77
• 期：11
• 页码：5161-5166
• 全文大小：314K
• 年卷期：v.77,no.11(June 1, 2012)
• ISSN：1520-6904

文摘

The first total synthesis of natural, unsymmetrical 2鈥?3鈥?diacyloxy-p-terphenyls, thelephantin O (1) and terrestrins C and D (2 and 3, respectively), was achieved via a practical route which was also applicable to the synthesis of the symmetrical diesters vialinin A/terrestrin A (4) and terrestrin B (5). Compounds 1鈥?b>5 exhibited cytotoxicity against cancer cells (HepG2 and Caco2) with IC₅₀ values of 13.6鈥?6.7 渭mol/L.