Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

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• 作者：Ian B. Seiple ; Shun Su ; Rodrigo A. Rodriguez ; Ryan Gianatassio ; Yuta Fujiwara ; Adam L. Sobel ; Phil S. Baran
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：September 29, 2010
• 年：2010
• 卷：132
• 期：38
• 页码：13194-13196
• 全文大小：267K
• 年卷期：v.132,no.38(September 29, 2010)
• ISSN：1520-5126

文摘

A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.