文摘
We report here the ruthenium-catalyzed selective monoarylation of aromatic ketones bearing two ortho carbon–heteroatom (O or N) bonds. Under the newly developed catalyst system consisting of RuHCl(CO)(PiPr3)2, CsF, and styrene, the C–O arylation of 2′,6′-dimethoxyacetophenone with a phenylboronate gave the C–O monoarylation product selectively. The selective C–O monoarylation was applicable to a variety of arylboronates and aromatic ketones and proceeds with high regio- and chemoselectivities. A formal synthesis of altertenuol was also achieved using the C–O monoarylation of an aromatic ester as a key step.