Rh-Catalyzed Intermolecular Carbenoid Functionalization of Aromatic C鈥揌 Bonds by 伪-Diazomalonates

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• 作者：Wai-Wing Chan ; Siu-Fung Lo ; Zhongyuan Zhou ; Wing-Yiu Yu
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：August 22, 2012
• 年：2012
• 卷：134
• 期：33
• 页码：13565-13568
• 全文大小：335K
• 年卷期：v.134,no.33(August 22, 2012)
• ISSN：1520-5126

文摘

A Rh-catalyzed intermolecular coupling of diazomalonates with arene C鈥揌 bonds is reported. The reaction is initiated by electrophilic C鈥揌 activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross-couple with diazomalonates with excellent regioselectivities and functional group tolerance, and thus, this reaction offers a new route to 伪-aryl carbonyl compounds for specific applications.