Cytotoxic Guanidine Alkaloids from Pterogyne nitens

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• 作者：Luis Octvio Regasini ; Ian Castro-Gamboa ; Dulce Helena Siqueira Silva ; Maysa Furlan ; Eliezer Jesus Barreiro ; Paulo Michel Pinheiro Ferreira ; Cludia Pessoa ; Letcia Veras Costa Lotufo ; Manoel Odorico de
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：March 27, 2009
• 年：2009
• 卷：72
• 期：3
• 页码：473-476
• 全文大小：94K
• 年卷期：v.72,no.3(March 27, 2009)
• ISSN：1520-6025

文摘

As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.