Stabilization of Folded Peptide and Protein Structures via Distance Matching with a Long, Rigid Cross-Linker

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• 作者：Fuzhong Zhang ; Oleg Sadovski ; Steven J. Xin ; G. Andrew Woolley
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：November 21, 2007
• 年：2007
• 卷：129
• 期：46
• 页码：14154 - 14155
• 全文大小：93K
• 年卷期：v.129,no.46(November 21, 2007)
• ISSN：1520-5126

文摘

Intramolecular cross-linking is predicted to stabilize the folded state of peptides and proteins most effectively if the cross-linker provides a rigid link that is well-matched in end-to-end distance with attachment sites in the peptide or protein. We describe a thiol-reactive sulfonated alkyne-based cross-linker that is demonstrably more effective than more flexible counterparts. Exceptional stabilization of helical structure in short peptides is obtained.