Oxidative Burst Inhibitory and Cytotoxic Indoloquinazoline and Furoquinoline Alkaloids from Oricia suaveolens
详细信息 查看全文
- 作者：Jean Duplex Wansi ; M. Ahmed Mesaik ; David Dako Chiozem ; Krishna Prasad Devkota ; Nicolas Gaboriaud-Kolar ; Marie-Christine Lallemand ; Jean Wandji ; M. Iqbal Choudhary ; Norbert Sewald
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：December 1, 2008
- 年：2008
- 卷：71
- 期：11
- 页码：1942-1945
- 全文大小：125K
- 年卷期：v.71,no.11(December 1, 2008)
- ISSN：1520-6025
文摘
Two new β-indoloquinazoline alkaloids, orisuaveoline A (1) and orisuaveoline B (2), two new furoquinoline alkaloids, quinosuaveoline A (5) and quinosuaveoline B (6), and 12 known compounds were isolated from Oricia suaveolens. The structures of the new compounds were deduced by spectroscopic studies. The absolute configuration of nkolbisine (4) was also determined. Compounds 2, 3, 6−8, 10, and 14 were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against A549 lung carcinoma cells.