Mixture of Nonionic/Ionic Surfactants for the Formulation of Nanostructured Lipid Carriers: Effects on Physical Properties

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• 作者：Shuangni Zhao ; Xiaomin Yang ; Vasil M. Garamus ; Ulrich A. Handge ; Luthringer B茅reng猫re ; Lin Zhao ; Gabriele Salamon ; Regine Willumeit ; Aihua Zou ; Saijun Fan
• 刊名：Langmuir
• 出版年：2014
• 出版时间：June 17, 2014
• 年：2014
• 卷：30
• 期：23
• 页码：6920-6928
• 全文大小：462K
• 年卷期：v.30,no.23(June 17, 2014)
• ISSN：1520-5827

文摘

The objective of the present work was to investigate the effects of the mixture of nonionic/ionic surfactants on nanostructured lipid carriers (NLCs). Nonionic surfactant (polyethylene鈥損oly(propylene glycol), Pluronic F68) and ionic surfactant (octenylsuccinic acid modified gum arabic, GA-OSA) were chosen as emulsifier for NLCs. The NLCs systems, which were composed of lipid matrix, modified 4-dedimethylaminosancycline (CMT-8), and various emulsifier agents, were characterized with dynamic light scattering (DLS), high performance liquid chromatography (HPLC), transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), in vitro release, and phagocytosis assay. This mixture of nonionic/ionic surfactants showed significant effects on physical properties including particle size, polydispersity index (PDI), entrapment efficiency, and particle morphology. Compared with single stabilizer, this mixed nonionic/ionic surfactant system provided NLCs with better drug carrier properties including prolonged release profile and low phagocytosis by phagocyte. We expect that these explorations can provide a new strategy for the development of lipid nanoparticles as drug delivery.