Isocyanides and Arylacetic Acids: Synthesis and Reactivity of 3-Aryl-2-acyloxyacrylamides, an Example of Serendipity-Oriented Synthesis

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• 作者：Andrea Basso ; Luca Banfi ; Andrea Galatini ; Giuseppe Guanti ; Federico Rastrelli ; Renata Riva
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：September 17, 2009
• 年：2009
• 卷：11
• 期：18
• 页码：4068-4071
• 全文大小：138K
• 年卷期：v.11,no.18(September 17, 2009)
• ISSN：1523-7052

文摘

Research progress is often promoted by unexpected results that open the way to new scenarios. In this communication, an unprecedented condensation of arylacetic acids and isocyanides and the unusual base-mediated rearrangement of the resulting products to give two novel classes of polysubstituted pyrrolones and pyrrolidinediones are reported.