Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens

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• 作者：Robin B. Bedford ; Peter B. Brenner ; Steven J. Durrant ; Timothy Gallagher ; Carolina Méndez-Gálvez ; Michelle Montgomery
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：81
• 期：9
• 页码：3473-3478
• 全文大小：317K
• 年卷期：0
• ISSN：1520-6904

文摘

The palladium-catalyzed ortho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method used.