Microencapsulation of Coenzyme Q10 in Poly(ethylene glycol) and Poly(lactic acid) with Supercritical Carbon Dioxide

详细信息    查看全文

• 作者：Mar铆a del Socorro Vergara-Mendoza ; Ciro-Humberto Ortiz-Estrada ; Juana Gonz谩lez-Mart铆nez ; Jes煤s-Alberto Quezada-Gallo
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2012
• 出版时间：May 2, 2012
• 年：2012
• 卷：51
• 期：17
• 页码：5840-5846
• 全文大小：507K
• 年卷期：v.51,no.17(May 2, 2012)
• ISSN：1520-5045

文摘

The rapid expansion of supercritical solutions (RESS) process was applied to produce polymeric microparticles loaded with coenzyme Q₁₀ (coQ₁₀). Mixtures of poly(lactic acid) (PLA)/(coQ₁₀) and poly(ethylene glycol) (PEG)/(coQ₁₀) containing a cosolvent were dissolved in supercritical CO₂ and sprayed through a nozzle to atmospheric pressure. The effect of process parameters such as encapsulating material/coQ₁₀ ratio and cosolvent on the properties of the microcapsules were investigated. The characterization of microcapsules was carried out through Scanning Electronic Microscopy (SEM), Infrared Spectrophotometry (IR), Differential Scanning Calorimetry (DSC), and solubility kinetics. More important effect of the ratio encapsulating material/coQ₁₀, compared with the effect of type of cosolvent, on studied properties was found.