Cordifolide A, a Sulfur-Containing Clerodane Diterpene Glycoside from Tinospora cordifolia
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- 作者：Li Pan ; Cesar Terrazas ; Claudio M. Lezama-Davila ; Nirmala Rege ; Judith C. Gallucci ; Abhay R. Satoskar ; A. Douglas Kinghorn
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：April 20, 2012
- 年：2012
- 卷：14
- 期：8
- 页码：2118-2121
- 全文大小：206K
- 年卷期：v.14,no.8(April 20, 2012)
- ISSN：1523-7052
文摘
Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolide A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs).