Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents

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• 作者：Shigui Chen ; Yian Ruan ; Jason D. Brown ; Judith Gallucci ; Veselin Maslak ; Christopher M. Hadad ; Jovica D. Badji膰
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：October 9, 2013
• 年：2013
• 卷：135
• 期：40
• 页码：14964-14967
• 全文大小：289K
• 年卷期：v.135,no.40(October 9, 2013)
• ISSN：1520-5126

文摘

We designed basket 1 to comprise a C₃-symmetric hydrophobic cage (477 脜³) at its southern edge and three polar ammonium caps at the northern edge. This amphiphilic molecule was observed to assemble into large unilamellar vesicles (350 nm, TEM) in water and thereby entrap dimethyl phenylphosphonate (184 脜³) in its cavity (K_app = (1.97 卤 0.02) 脳 10³ M^鈥?). The entrapment of the organophosphonate, akin to soman in size (186 脜³), triggers the transformation of the vesicular material into nanoparticles (100 nm, TEM). Stimuli-responsive vesicles, containing baskets of type 1 in their bilayer membrane, are unique assemblies and important for obtaining novel sensing devices.