Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation
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- 作者：Bryan Ronain Smith ; Paul Kempen ; Donna Bouley ; Alexander Xu ; Zhuang Liu ; Nicholas Melosh ; Hongjie Dai ; Robert Sinclair ; Sanjiv Sam Gambhir
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：July 11, 2012
- 年：2012
- 卷：12
- 期：7
- 页码：3369-3377
- 全文大小：472K
- 年卷期：v.12,no.7(July 11, 2012)
- ISSN：1530-6992
文摘
Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous.