An Unprecedented Neolignan Skeleton from Chimarrhis turbinata

详细信息    查看全文

• 作者：Carmen L. Cardoso ; Ian Castro-Gamboa ; Giovana M. Bergamini ; Alberto J. Cavalheiro ; Dulce H. S. Silva ; Marcia N. Lopes ; Angela R. Arau虂jo ; Maysa Furlan ; Hugo Verli ; Vanderlan da S. Bolzani
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：March 25, 2011
• 年：2011
• 卷：74
• 期：3
• 页码：487-491
• 全文大小：741K
• 年卷期：v.74,no.3(March 25, 2011)
• ISSN：1520-6025

文摘

A lignan with a new skeleton named chimarrhinin (1) was isolated from an extract of the leaves of Chimarrhis turbinata, a Rubiaceae plant species. up>13up>C NMR spectrometric techniques including 1D and 2D experiments and HRESIMS provided unequivocal structural confirmation of this new Cub>6ub>.Cub>3ub> skeleton type. The relative configuration of 1 was established by 2D up>1up>H鈭扝 analysis and J couplings, while its conformation was evaluated through molecular modeling using the RM1 semiempirical method, with the aid of coupling constants obtained by NMR analysis. The antioxidant activity of the new derivative 1 and two known and previously isolated phenolic derivatives (2 and 3) was investigated. An ICub>50ub> value of 7.50 卤 0.5 渭mol Lup>鈭?up> was obtained for the new derivative 1, while 2 and 3 showed ICub>50ub> values of 18.60 卤 0.4 and 18.50 卤 0.6 渭mol, respectively.