Low Temperature and Template-Free Synthesis of Hollow Hydroxy Zinc Phosphate Nanospheres and Their Application in Drug Delivery

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• 作者：Xiaoya Yuan ; Bangshang Zhu ; Xiaofei Ma ; Gangsheng Tong ; Yue Su ; Xinyuan Zhu
• 刊名：Langmuir
• 出版年：2013
• 出版时间：October 1, 2013
• 年：2013
• 卷：29
• 期：39
• 页码：12275-12283
• 全文大小：457K
• 年卷期：v.29,no.39(October 1, 2013)
• ISSN：1520-5827

文摘

Hollow hydroxy zinc phosphate nanospheres (HZnPNSs) with sizes of 30鈥?0 nm and wall thicknesses of about 7 nm were synthesized using a template-free method through wet precipitation of Zn(NO₃)₂路6H₂O and (NH₄)₂HPO₄ at temperatures of 0, 10, and 20 掳C. The crystal structures, morphologies, sizes and pore properties, Zn/P molar ratios, and thermal stability properties of nanoparticles have been carefully examined. The methyl-thiotetrazole assay measurements proved the low cell cytotoxicity of the material. The protein adsorption of negatively charged bovine serum albumin (BSA) and positively charged lysozyme on HZnPNSs was also investigated. The results showed that HZnPNSs had high protein adsorption affinity. Furthermore, anticancer doxorubicin as a model drug was used to evaluate the entrapment efficiency and drug loading capacity of HZnPNSs, which showed high loading capacity (>16 wt %) for doxorubicin. The confocal laser scanning microscope observations showed that the drug could be efficiently delivered into cells.