Regioselective Cobalt-Catalyzed Formation of Bicyclic 3- and 4-Aminopyridines

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• 作者：Pierre Garcia ; Yannick Evanno ; Pascal George ; Mireille Sevrin ; Gino Ricci ; Max Malacria ; Corinne Aubert ; Vincent Gandon
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：April 15, 2011
• 年：2011
• 卷：13
• 期：8
• 页码：2030-2033
• 全文大小：807K
• 年卷期：v.13,no.8(April 15, 2011)
• ISSN：1523-7052

文摘

Bimolecular cobalt-catalyzed [2 + 2 + 2] cycloadditions between yne鈭抷namides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion.