Diversity Oriented Synthesis of Pyrrolidines via Natural Carbohydrate Solid Acid Catalyst

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• 作者：Atul Kumar ; Garima Gupta ; Suman Srivastava
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2010
• 出版时间：July 12, 2010
• 年：2010
• 卷：12
• 期：4
• 页码：458-462
• 全文大小：232K
• 年卷期：v.12,no.4(July 12, 2010)
• ISSN：1520-4774

文摘

Natural carbohydrate scaffold catalyzed diastereoselective synthesis of functionalized pyrrolidines have been developed via 1,3-dipolar cycloaddition of azomethine ylides derived from α-imino esters with dienes or dipolarophiles. Naturally most abundant carbohydrates, like cellulose and starch, were converted into their sulfuric acid derivative, which are exhibiting efficient catalytic properties, along with excellent cost effectivity and recyclability. The advantages of this methodology are diversity oriented metal free synthesis of functionalized pyrrolidines, mild reaction condition, high diasteroselectivity and yield.