Potentiality of Gas Chromatography-Triple Quadrupole Mass Spectrometry in Vanguard and Rearguard Methods of Pesticide Residues in Vegetables

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• 作者：Antonia Garrido Frenich ; Manuel J. Gonzá ; lez-Rodrí ; guez ; Francisco J. Arrebola ; and José ; L. Martí ; nez Vidal
• 刊名：Analytical Chemistry
• 出版年：2005
• 出版时间：July 15, 2005
• 年：2005
• 卷：77
• 期：14
• 页码：4640 - 4648
• 全文大小：106K
• 年卷期：v.77,no.14(July 15, 2005)
• ISSN：1520-6882

文摘

A new analytical strategy for the screening and confirmation/quantification of multiclass pesticide residues invegetables has been established and validated. No complicated sample preparation was needed, but only asimple and rapid extraction using ethyl acetate andsodium sulfate, which required no cleanup. The approachis based on the use of the triple quadrupole (QqQ) massspectrometry (MS) as detection system in gas chromatography (GC). In a first step, a GC-QqQ-MS screeningmethod, which monitors only one MS/MS transition bycompound, allows the identification of ~130 pesticidesin 11.6 min. In this way, the differentiation betweennegative and potentially nonnegative samples is carriedout. In the second step, the nonnegative samples arereanalyzed by the GC-QqQ-MS confirmation/quantification method, which monitors two or three MS/MS transitions by compound. Confirmation of pesticides was basedon the comparison of intensity ratios for the main ions insamples with those obtained on the same day from thestandard in a matrix containing the pesticides at apreestablished concentration level. Quantification of theidentified and confirmed pesticides was based on theaddition standard method, which avoids matrix effect. Theproposed analytical strategy allowed a reliable identification and confirmation of the target pesticides at tracelevels, reducing analysis time and increasing samplethroughput in routine analytical laboratories.