Synthesis of the Tetrasaccharide Repeating Unit of the 尾-Kdo-Containing Exopolysaccharide from Burkholderia pseudomallei and B. cepacia Complex
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- 作者：Ana茂s Laroussarie ; Barbara Barycza ; Hanitra Andriamboavonjy ; Marielle Tamigney Kenfack ; Yves Bl茅riot ; Charles Gauthier
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：October 16, 2015
- 年：2015
- 卷：80
- 期：20
- 页码：10386-10396
- 全文大小：521K
- ISSN：1520-6904
文摘
The synthesis of the repeating unit of the immunogenic 尾-Kdo-containing exopolysaccharide produced by Burkholderia pseudomallei and bacteria of the B. cepacia complex is described. The target tetrasaccharide was synthesized via stereoselective 1,2-cis- and 1,2-trans-galactosylations and 尾-Kdosylation. A [3 + 1] coupling reaction between a trigalactosyl N-phenyl-2,2,2-trifluoroacetimidate donor and a Kdo acceptor has been successfully achieved for the assembly of the tetrasaccharide skeleton.