Asymmetric Transfer Hydrogenation of Acetophenone with 1R,2S-Aminoindanol/Pentamethylcyclopentadienylrhodium Catalyst

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• 作者：Xiuyan Sun ; George Manos ; John Blacker ; Juliette Martin ; and Asterios Gavriilidis
• 刊名：Organic Process Research & Development
• 出版年：2004
• 出版时间：November 2004
• 年：2004
• 卷：8
• 期：6
• 页码：909 - 914
• 全文大小：228K
• 年卷期：v.8,no.6(November 2004)
• ISSN：1520-586X

文摘

The chiral rhodium complex pentamethylcyclopentadienylrhodium chloride dimer combined with the ligand 1R,2S-aminoindanol provides a superior catalyst for the rapid, high-yielding asymmetric transfer hydrogenation of acetophenonewith 2-propanol to produce (R)- and (S)-(1)-phenylethanol. Theeffects of various reaction parameters such as reaction temperature, catalyst and substrate concentration, gaseous environment, and acetone concentration on conversion and enantioselectivity were investigated. The results indicate that catalystcan be deactivated by high temperature and air atmosphere,acetone reduces the reaction rate, and enantioselectivity decreases with conversion.