Continuous-Flow Synthesis of meta-Substituted Phenol Derivatives

详细信息    查看全文

• 作者：Jeong Hyeon Park ; Chan Yi Park ; Mi Jin Kim ; Min Uk Kim ; Young Joon Kim ; Geon-Hee Kim ; Chan Pil Park
• 刊名：Organic Process Research & Development
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：19
• 期：7
• 页码：812-818
• 全文大小：398K
• ISSN：1520-586X

文摘

Two complementary microreactor technologies were developed for the study of biphasic gas鈥搇iquid reactions and preparation of meta-substituted phenol derivatives. The first capillary microreactor, composed of a T-junction and simple capillary, enabled oxidative Heck/dehydrogenation on a microgram scale with a shortened reaction time; the total sequence time for oxidative Heck/dehydrogenation reactions was optimized from 2160 min in a traditional batch system to 130 min in the microchemical system. The second tube-in-tube microreactor, composed of a gas-permeable inner tube and gas-nonpermeable outer tube, successfully performed a gram-scale synthesis under the optimized safety and economic conditions which were established from the first microgram-scale study. The two microreactors have great potential for exploring reactions involving gaseous and liquid reagents.