Rapid Synthesis of 1,3,5-Substituted 1,2,4-Triazoles from Carboxylic Acids, Amidines, and Hydrazines

详细信息    查看全文

• 作者：Georgette M. Castanedo ; Pamela S. Seng ; Nicole Blaquiere ; Sean Trapp ; Steven T. Staben
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：February 18, 2011
• 年：2011
• 卷：76
• 期：4
• 页码：1177-1179
• 全文大小：696K
• 年卷期：v.76,no.4(February 18, 2011)
• ISSN：1520-6904

文摘

A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles.