Drug Delivery with a Calixpyrrole鈥?i>trans-Pt(II) Complex

详细信息    查看全文

• 作者：Grazia Cafeo ; Grazia Carbotti ; Angela Cuzzola ; Marina Fabbi ; Silvano Ferrini ; Franz H. Kohnke ; Georgia Papanikolaou ; Maria Rosaria Plutino ; Camillo Rosano ; Andrew J. P. White
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：February 20, 2013
• 年：2013
• 卷：135
• 期：7
• 页码：2544-2551
• 全文大小：415K
• 年卷期：v.135,no.7(February 20, 2013)
• ISSN：1520-5126

文摘

A meso-p-nitroaniline-calix[4]pyrrole derivative trans-coordinated to a Pt(II) center was synthesized and its structure solved by X-ray analysis. Adenosine monophosphate (AMP) was used as a model compound to evaluate the potential for the assisted delivery of the metal to the DNA nucleobases via the phosphate anion-binding properties of the calix[4]pyrrole unit. An NMR investigation of the kinetics of AMP complexation in the absence of an H-bonding competing solvent (dry CD₃CN) was consistent with this hypothesis, but we could not detect the interaction of the calix[4]pyrrole with phosphate in the presence of water. However, in vitro tests of the new trans-calixpyrrole鈥揚t(II) complex on different cancer cell lines indicate a cytotoxic activity that is unquestionably derived from the coexistence of both the trans-Pt(II) fragment and the calix[4]pyrrole unit.