Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica
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- 作者：Ignacio P茅rez-Victoria ; Jes煤s Mart铆n ; V铆ctor Gonz谩lez-Men茅ndez ; Nuria de Pedro ; Noureddine El Aouad ; Francisco Javier Ortiz-L贸pez ; Jos茅 Rub茅n Tormo ; Gonzalo Platas ; Francisca Vicente ; Gerald F. Bills ; Olga Genilloud ; Michael A. Goetz ; Fernando Reyes
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：June 22, 2012
- 年：2012
- 卷：75
- 期：6
- 页码：1210-1214
- 全文大小：233K
- 年卷期：v.75,no.6(June 22, 2012)
- ISSN：1520-6025
文摘
Three new cyclic tetrapeptides (1鈥?b>3) have been isolated from the crude fermentation extract of Onychocola sclerotica. The planar structures of 1鈥?b>3 were elucidated by detailed spectroscopic analyses using one- and two-dimensional NMR experiments and high-resolution mass spectrometry. The absolute configuration of the amino acid residues in each cyclotetrapeptide was established by Marfey鈥檚 method. Compounds 1鈥?b>3 displayed activity as cardiac calcium channel blockers (Cav1.2) but did not inhibit the hERG potassium channel and were not cytotoxic. These peptides are the first secondary metabolites ever reported from fungi of the order Arachnomycetales.