Cytotoxic Clerodane Diterpenoids from Casearia obliqua
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- 作者：Gerardo Magela Vieira Jnior ; Tiago de Oliveira Gonalves ; Luis O. Regasini ; Paulo M. Pinheiro Ferreira ; Cludia do Pessoa ; Letcia V. Costa Lotufo ; Roseli Buzanelli Torres ; Nivaldo Boralle ; Vanderlan da
- 刊名：Journal of Natural Products
- 出版年：2009
- 出版时间：October 23, 2009
- 年：2009
- 卷：72
- 期：10
- 页码：1847-1850
- 全文大小：172K
- 年卷期：v.72,no.10(October 23, 2009)
- ISSN：1520-6025
文摘
A crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led to the isolation of the known clerodane diterpenes rel-6β-hydroxyzuelanin-2β-benzoate and rel-2α-hydroxyzuelanin-6β-benzoate (3 and 4) as a mixture and 2β-hydroxyzuelanin-6β-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound 1 and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines.