Highly diastereoselective and enantioselective addition of
N-benzylhydroxylamine to imides
17 and
20-
30 produces
![](/images/gifchars/alpha.gif)
,
![](/images/gifchars/beta2.gif)
-trans-disubstituted
N-benzylisoxazolidinones
19 and
31-
41. These reactions proceed in 60-96% ee with 93-99% de's using 5 mol % of Mg(NTf
2)
2 and ligand
18. The product isoxazolidinones can be hydrogenolyzed directly to provide
![](/images/gifchars/alpha.gif)
,
![](/images/gifchars/beta2.gif)
-disubstituted-
![](/images/gifchars/beta2.gif)
-amino acids.