Measurement and Modeling Process Partitioning of Cephalexin Antibiotic in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) 4000, 10000 and K2HPO4, Na3Citrate

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• 作者：Khadijeh Khederlou ; Gholam Reza Pazuki ; Vahid Taghikhani ; Manoucher Vossoughi ; Cyrus Ghotbi
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2009
• 出版时间：August 13, 2009
• 年：2009
• 卷：54
• 期：8
• 页码：2239-2244
• 全文大小：113K
• 年卷期：v.54,no.8(August 13, 2009)
• ISSN：1520-5134

文摘

In this work, the partition coefficients of Cephalexin in aqueous two-phase systems containing PEG [poly(ethylene glycol)] 4000, 10000 and K₂HPO₄, Na₃Citrate (C₆H₅Na₃O₇ 5, 5H₂O) have been measured. The experimental data were obtained in a wide range of temperatures, (28.2 to 37.2) °C. The effects of temperature, pH, polymer concentration, polymer molecular weight, and salt concentration on the partitioning of Cephalexin were also studied. The results showed that salt concentration has a large effect on the partition coefficient, and temperature has an almost negligible effect. The Chen−NRTL Gibbs energy model was used to correlate the experimental results.